Mechanistic Investigation of the Time-Dependent Aldehyde Oxidase Inhibitor Hydralazine

Data Supplement

• Supplemental Figures -

  Supplemental Figure S1. MS/MS spectrum and proposed structure of the 1-phthalazyl-N-acetylcysteine conjugate detected in extracts from co-incubation of hydralazine and N-acetylcysteine in potassium phosphate buffer containing human liver cytosol.

  Supplemental Figure S2. MS/MS spectrum and proposed structure of the 1-phthalazyl-glutathione conjugate detected in extracts from co-incubation of hydralazine and GSH in potassium phosphate buffer containing human liver cytosol.

  Supplemental Figure S3. Formation of the 1-phthalazyl-GSH conjugate in potassium phosphate buffer in the presence and absence of EDTA.