The Cytochrome P450 (CYP) 2C8*3 Variant (rs11572080) is Associated with Improved Asthma Symptom Control in Children and Altered Lipid Mediator Production and Inflammatory Response in Human Bronchial Epithelial Cells

Data Supplement

• Supplemental Figure 1 -

  Supplemental Figure S1. Comparison of asthma control scores as a function of CYP2C8 genotype in a population of children with asthma.

• Supplemental Figure 2 -

  Supplemental Figure S2. CYP epoxygenase expression in epithelial cells from proximal and distal portions of the airway.
  

• Supplemental Figure 3 -

  Supplemental Figure S3. Volcano plot representation of the concentrations of non-esterified oxylipins, endocannabinoids and polyunsaturated fatty acids detected in cell culture media from cells engineered to overexpress CYP2C8*1 versus cells engineered to overexpress CYP2C8*3.
  

• Supplemental Figure 4 -

  Supplemental Figure S4. Representative LC-MS/MS chromatograms for cell incubations with LA.
  

• Supplemental Figure 5 -

  Supplemental Figure S5. Montelukast 1,2-diol formation by cells engineered to overexpress CYP2C8*1 and CYP2C8*3 in the presence and absence of quercetin (75µM), an inhibitor of CYP2C8.