PT  - JOURNAL ARTICLE
AU  - H D Dell
AU  - J Fielder
AU  - R Kamp
AU  - W Gau
AU  - J Kurz
AU  - B Weber
AU  - C Wuensche
TI  - Etofenamate fatty acid asters. An example of a new route of drug metabolism.
DP  - 1982 Jan 01
TA  - Drug Metabolism and Disposition
PG  - 55--60
VI  - 10
IP  - 1
4099  - http://dmd.aspetjournals.org/content/10/1/55.short
4100  - http://dmd.aspetjournals.org/content/10/1/55.full
SO  - Drug Metab Dispos1982 Jan 01; 10
AB  - Etofenamate [2-(2-hydroxyethoxy)ethyl-N-(alpha, alpha, alpha-trifluoro-m-tolyl)-anthranilate] was administered to dogs by the oral route. Minor amounts of etofenamate (Eto) and its glucuronide were found in urine and feces. The main portion of metabolites was eliminated as flufenamic acid (Flu) and hydroxy derivatives of Eto and Flu. Furthermore, a highly lipophilic fraction was isolated (extraction and TLC) and further separated into several compounds (HPLC, GLC). These metabolites were identified as Eto oleate, palmitate, linoleate, stearate, palmitoleate, myristate, and laurate by NMR and MS. The structures were confirmed by comparison with authentic material. The conjugation of etofenamate with fatty acids is an example of a new route of drug metabolism.