RT Journal Article SR Electronic T1 The metabolism of (R)-(-)-amphetamine by rabbit liver microsomes. Initial products. JF Drug Metabolism and Disposition JO Drug Metab Dispos FD American Society for Pharmacology and Experimental Therapeutics SP 312 OP 315 VO 10 IS 4 A1 V M Florence A1 E W Di Stefano A1 C Y Sum A1 A K Cho YR 1982 UL http://dmd.aspetjournals.org/content/10/4/312.abstract AB The metabolism of 1-amphetamine in rabbit liver is complex in that several routes may give rise to the same intermediate. In this study, the subsequent metabolism of the primary products of N- and C-oxidation were blocked by selecting appropriate incubation conditions. The resulting simplified system was used to investigate the enzymes involved in the two pathways. Phenobarbital treatment increased N- and C-hydroxylation, whereas 3-methylcholanthrene treatment had an inhibitory effect on both pathways. Inhibitors of cytochrome P-450 were either nonselective or were partially selective in inhibiting the two routes of amphetamine metabolism. Induction modulated the sensitivity toward the inhibitors of N- and C-oxidation.