RT Journal Article SR Electronic T1 Salicylate enhancement of renal glucuronide conjugation and tubular excretory transfer of phenols. JF Drug Metabolism and Disposition JO Drug Metab Dispos FD American Society for Pharmacology and Experimental Therapeutics SP 573 OP 578 VO 10 IS 6 A1 G L Diamond A1 M W Anders A1 L M Tremaine A1 A J Quebbemann YR 1982 UL http://dmd.aspetjournals.org/content/10/6/573.abstract AB Salicylate administration increased glucuronyltransferase activity, with o-aminophenol as the substrate, in chicken kidney homogenates, but did not affect glucuronyltransferase activity in chicken liver homogenates. In addition, salicylate administration increased in vivo renal glucuronidation of catechol and p-nitrophenol without affecting renal sulfate conjugation of these compounds. These results suggest that salicylate administration selectively enhances renal glucuronide conjugation, thereby promoting a more rapid metabolism and elimination of circulating phenols, especially at high plasma phenol concentrations. Isolated human kidney perfusion experiments reveal that glucuronide and sulfate conjugates of phenol, p-nitrophenol, and 1-naphthol are formed in the human kidney, suggesting that the effect of salicylate treatment on renal glucuronidation may apply to humans.