TY - JOUR T1 - Acylation of albumin by 1-O-acyl glucuronides. JF - Drug Metabolism and Disposition JO - Drug Metab Dispos SP - 318 LP - 320 VL - 13 IS - 3 AU - R B van Breemen AU - C Fenselau Y1 - 1985/05/01 UR - http://dmd.aspetjournals.org/content/13/3/318.abstract N2 - Representative examples of drug metabolites containing a carboxylic acid group conjugated to glucuronic acid are shown to be active chemical electrophiles, which acylate albumin in vitro through transesterification reactions. Based on these and other observations, we propose that this acylating reactivity is characteristic of 1-O-acyl glucuronides as a class, and that albumin is representative of many susceptible biopolymers. The hypothesis is advanced that this reaction can occur in vivo as well, and that it may offer a molecular mechanism for the physiological activity or toxicity of some xenobiotic and lipophilic compounds. ER -