RT Journal Article
SR Electronic
T1 Hepatic mixed function oxidases and cytochrome P-450 contents in rat pups exposed to di-(2-ethylhexyl)phthalate through mother's milk.
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 368
OP 370
VO 13
IS 3
A1 D Parmar
A1 S P Srivastava
A1 S P Srivastava
A1 P K Seth
YR 1985
UL http://dmd.aspetjournals.org/content/13/3/368.abstract
AB Effects of di-(2-ethylhexyl)phthalate (DEHP) on the detoxification mechanisms of xenobiotics were investigated in neonatal rat pups of mothers receiving 2000 mg phthalate/kg daily from day 1 of birth. The nursing rat pups of mothers exposed to DEHP showed decreases in body weight gain and activities of aniline hydroxylase, ethylmorphine N-demethylase, and arylhydrocarbon hydroxylase and decreased levels of cytochrome P-450 at 21 days of age. Significant quantities of DEHP were also detected in the liver of pups in this interval. These results suggest that the livers of developing animals could be affected by the lactational transfer of DEHP, a commonly used plasticizer.