RT Journal Article
SR Electronic
T1 METABOLISM OF TETRALIN AND TOXICITY OF CUPREX IN MAN
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 577
OP 579
VO 1
IS 3
A1 DENNIS E. DRAYER
A1 MARCUS M. REIDENBERG
YR 1973
UL http://dmd.aspetjournals.org/content/1/3/577.abstract
AB A patient ingested about 250 ml of Cuprex, an ectoparasiticide containing tetralin (1,2,3, 4-tetrahydronaphthalene). copper oleate, paraffin oil, and acetone, in an episode of self-poisoning. This caused a mild degree of liver and kidney damage that subsided within two weeks. The main urinary metabolite of tetralin was 1,2,3,4-tetrahydro-1-naphthol. The glucuronides of this naphthol and of 1,2,3,4-tetrahydro-2-naphthol were also detected in the urine. Hydroxylation of tetralin only on the alicyclic ring and mainly at the benzylic carbon suggests that tetralin metabolism may occur via a pathway involving the formation of free radicals. Copyright © 1973 by The American Society for Pharmacology and Experimental Therapeutics