TY - JOUR T1 - Synthesis, characterization, and quantitation of para-hydroxymethadone, a metabolite of methadone in the rat. JF - Drug Metabolism and Disposition JO - Drug Metab Dispos SP - 477 LP - 481 VL - 14 IS - 4 AU - B M Gerardy AU - D Kapusta AU - P Dumont AU - J H Poupaert Y1 - 1986/07/01 UR - http://dmd.aspetjournals.org/content/14/4/477.abstract N2 - To demonstrate a p-hydroxylation process in the metabolism of methadone, we have synthesized para-hydroxymethadone and characterized it by spectroscopy (IR, 13C-NMR, mass spectrometry) and chromatography (thin layer chromatography, gas-liquid chromatography, and HPLC). para-Hydroxymethadone was isolated by HPLC from the urine of rats treated with (R,S)-methadone. para-Hydroxymethadone in the urine and in the bile represents 1.82 and 38.08%, respectively, of the administered dose. para-Hydroxymethadone does not exhibit any opioid-like activity. ER -