TY - JOUR T1 - CHANGES IN RATE OF ETHANOL ELIMINATION ASSOCIATED WITH CHRONIC ADMINISTRATION OF ETHANOL TO CHIMPANZEES AND RHESUS MONKEYS JF - Drug Metabolism and Disposition JO - Drug Metab Dispos SP - 634 LP - 641 VL - 1 IS - 4 AU - W. A. PIEPER AU - MARIANNE J. SKEEN Y1 - 1973/07/01 UR - http://dmd.aspetjournals.org/content/1/4/634.abstract N2 - Increases in ethanol elimination rate were found in seven young chimpanzees and three rhesus monkeys during periods of chronic ethanol ingestion. The duration of these periods ranged from 6-29 weeks and ethanol dose levels varied from approximately 2-9 g/kg/day. In both species the extent of elevation of elimination rate was found to be related to the magnitude of the ethanol dose rather than to the length of time that the animal had been consuming ethanol. That these changes in elimination rate were directly related to ethanol administration was further substantiated by the finding that the elevated elimination rates returned to baseline values during periods of abstinence. Additionally, repeated measurements in a control group of four chimpanzees indicated that no systematic developmental changes in elimination rate occurred during the age range of the animals used in this study if ethanol was not chronically administered. These results are discussed with respect to the disagreement among previous investigators as to whether or not adaptive changes in elimination rate occur in ethanol-treated organisms. Copyright © 1973 by The American Society for Pharmacology and Experimental Therapeutics ER -