PT  - JOURNAL ARTICLE
AU  - M. W. ANDERS
AU  - M. J. COOPER
AU  - A. E. TAKEMORI
TI  - KINETICS OF MICROSOMAL METABOLISM AND BINDING OF ENANTIOMERICALLY RELATED SUBSTRATES
DP  - 1973 Jul 01
TA  - Drug Metabolism and Disposition
PG  - 642--644
VI  - 1
IP  - 4
4099  - http://dmd.aspetjournals.org/content/1/4/642.short
4100  - http://dmd.aspetjournals.org/content/1/4/642.full
SO  - Drug Metab Dispos1973 Jul 01; 1
AB  - The kinetics of the hepatic microsomal N-demethylation and binding of enantiomerically related drugs has been studied. The Michaelis constants for metabolism did not differ between any of the enantiomers studied, whereas the maximal velocities differed between propoxyphene and methorphan enantiomers but not in the case of carbinoxamine enantiomers. Both the spectral binding constants and maximal spectral changes were different between propoxyphene enantiomers but not between carbinoxamine enantiomers; levomethorphan elicited a difference spectrum with microsomes, but dextromethorphan did not. Copyright © 1973 by The American Society for Pharmacology and Experimental Therapeutics