PT  - JOURNAL ARTICLE
AU  - I H Hall
AU  - D J Reynolds
AU  - S D Wyrick
AU  - J H Maguire
AU  - R P Shrewsbury
TI  - The disposition of the hypolipidemic agent, o-(N-phthalimido)acetophenone, in Sprague-Dawley rats.
DP  - 1988 Mar 01
TA  - Drug Metabolism and Disposition
PG  - 196--200
VI  - 16
IP  - 2
4099  - http://dmd.aspetjournals.org/content/16/2/196.short
4100  - http://dmd.aspetjournals.org/content/16/2/196.full
SO  - Drug Metab Dispos1988 Mar 01; 16
AB  - Disposition studies of the potent experimental hypolipidemic agent, o-(N-phthalimido)acetophenone, were conducted in the laboratory rat. Intravenous administration of the drug demonstrated a declining biphasic plasma concentration-time curve suggesting a rapid distribution into tissues. Less than 5% of the intravenous dose was recovered in urine and feces after 5 days. Oral administration of the drug showed that the maximum blood levels were attained within 15 min. After 48 hr, 92% of the orally administered 14C dose was eliminated either via urine (60%) or feces (40%). 14C in a 0-24-hr urine collection after oral administration showed that urinary radioactivity was composed of 22% of the parent compound o-(N-phthalimido) acetophenone, a benzoic acid metabolite (22%) o-(N-phthalimido)benzoic acid, and an amic acid metabolite (56%) N-(o-acetophenone)phthalamic acid. The two metabolites were unconjugated and possessed less hypolipidemic activity than the parent drug.