PT  - JOURNAL ARTICLE
AU  - D'Souza, M J
AU  - Pollock, S H
AU  - Solomon, H M
TI  - Cyclosporine-phenytoin interaction.
DP  - 1988 Mar 01
TA  - Drug Metabolism and Disposition
PG  - 256--258
VI  - 16
IP  - 2
4099  - http://dmd.aspetjournals.org/content/16/2/256.short
4100  - http://dmd.aspetjournals.org/content/16/2/256.full
SO  - Drug Metab Dispos1988 Mar 01; 16
AB  - Cyclosporine (CsA), an immunosuppressant, is used widely to prevent rejection of transplanted organs. It is extensively metabolized in the liver by hydroxylation and demethylation. Since phenytoin is used extensively post-transplant as an anti-convulsant, we studied the effect of chronic treatment with phenytoin on CsA by determining the disposition of CsA, prior to and after chronic treatment with phenytoin (30 mg/kg, po) for 5 days. CsA was analyzed by HPLC. The clearance (CL) of CsA was significantly enhanced following treatment with phenytoin when compared to the CL values obtained pretreatment (15.46 +/- 0.76 vs. 25.3 +/- 3.11 ml/min/kg). There were no significant changes in the volume of distribution of CsA. From the above data, we conclude that phenytoin probably induces the metabolism of CsA.