PT  - JOURNAL ARTICLE
AU  - de Waziers, I
AU  - Boisset, M
AU  - Atteba, S
TI  - Pre- and postweaning development of drug-metabolizing enzyme activities in small intestine and liver of rats.
DP  - 1988 Mar 01
TA  - Drug Metabolism and Disposition
PG  - 310--315
VI  - 16
IP  - 2
4099  - http://dmd.aspetjournals.org/content/16/2/310.short
4100  - http://dmd.aspetjournals.org/content/16/2/310.full
SO  - Drug Metab Dispos1988 Mar 01; 16
AB  - The postnatal development of NADPH-cytochrome c reductase, UDP-glucuronosyltransferase, selenium-dependent glutathione peroxidase, glutathione-S-transferase activities, total non-protein sulfhydryls, and cytochrome P-450 contents was compared in small intestine and liver of male Wistar rats from 18 to 60 days of life. In the intestine, main age-related changes affected conjugation enzymes which were increased rapidly by a factor of 4 during the weaning time and remained unchanged thereafter. Development in the rat was accompanied by changes in cytochrome P-450 content and NADPH-cytochrome c reductase activity only in the liver. In both organs, glutathione concentration and selenium-dependent glutathione peroxidase activity were not significantly modified between 18 and 60 days. In the liver, we observed discontinuities in the developmental pattern of UDP-glucuronosyltransferase, and the ontogenesis of glutathione-S-transferase activities differed according to the substrate metabolized.