RT Journal Article
SR Electronic
T1 Pre- and postweaning development of drug-metabolizing enzyme activities in small intestine and liver of rats.
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 310
OP 315
VO 16
IS 2
A1 de Waziers, I
A1 Boisset, M
A1 Atteba, S
YR 1988
UL http://dmd.aspetjournals.org/content/16/2/310.abstract
AB The postnatal development of NADPH-cytochrome c reductase, UDP-glucuronosyltransferase, selenium-dependent glutathione peroxidase, glutathione-S-transferase activities, total non-protein sulfhydryls, and cytochrome P-450 contents was compared in small intestine and liver of male Wistar rats from 18 to 60 days of life. In the intestine, main age-related changes affected conjugation enzymes which were increased rapidly by a factor of 4 during the weaning time and remained unchanged thereafter. Development in the rat was accompanied by changes in cytochrome P-450 content and NADPH-cytochrome c reductase activity only in the liver. In both organs, glutathione concentration and selenium-dependent glutathione peroxidase activity were not significantly modified between 18 and 60 days. In the liver, we observed discontinuities in the developmental pattern of UDP-glucuronosyltransferase, and the ontogenesis of glutathione-S-transferase activities differed according to the substrate metabolized.