PT  - JOURNAL ARTICLE
AU  - D W Clark
AU  - G N Smith
AU  - J Patrick
AU  - B Richardson
AU  - J F Brien
TI  - Disposition of ethanol and its proximate metabolite, acetaldehyde, in the near-term pregnant ewe for short term maternal administration of moderate-dose ethanol.
DP  - 1988 May 01
TA  - Drug Metabolism and Disposition
PG  - 464--468
VI  - 16
IP  - 3
4099  - http://dmd.aspetjournals.org/content/16/3/464.short
4100  - http://dmd.aspetjournals.org/content/16/3/464.full
SO  - Drug Metab Dispos1988 May 01; 16
AB  - The effect of short term maternal ethanol administration on the disposition of ethanol in the ovine maternal-fetal unit was determined. Eleven conscious instrumented near-term pregnant ewes (between 125 and 134 days of gestation; term, 147 days) received 1-hr iv infusion of 1 g of ethanol.kg of maternal body weight-1.day-1 for six days (N = 6 ewes) or an equivalent volume of saline for six days (N = 5 ewes). On the seventh day, the ethanol- and saline-pretreated animals were administered 1 g of ethanol.kg of maternal body weight-1. Ethanol and acetaldehyde concentrations were determined by headspace GLC in maternal blood, fetal blood, and amniotic fluid samples obtained at selected times during the 14-hr study. The data demonstrated that short term maternal administration of once-daily moderate dose ethanol did not produce major changes in the disposition of ethanol and its proximate metabolite, acetaldehyde, in the maternal, fetal, and amniotic fluid compartments during near-term ovine pregnancy.