PT  - JOURNAL ARTICLE
AU  - A Wahlström
AU  - K Persson
AU  - A Rane
TI  - Metabolic interaction between morphine and naloxone in human liver. A common pathway of glucuronidation?
DP  - 1989 Mar 01
TA  - Drug Metabolism and Disposition
PG  - 218--220
VI  - 17
IP  - 2
4099  - http://dmd.aspetjournals.org/content/17/2/218.short
4100  - http://dmd.aspetjournals.org/content/17/2/218.full
SO  - Drug Metab Dispos1989 Mar 01; 17
AB  - Metabolic interaction between naloxone and morphine has been studied in vitro in human liver microsomes. Morphine and naloxone are metabolized by an UDP-glucuronyl transferase to their 3-glucuronides. There is a very good correlation between the rates of formation of morphine-3-glucuronide and of naloxone-3-glucuronide. Naloxone seems to have a 10-fold higher affinity for the enzyme binding site than does morphine. Morphine and naloxone show bisubstrate kinetic patterns which appear very similar.