RT Journal Article
SR Electronic
T1 SECLAZONE: BIOTRANSFORMATION DURING ABSORPTION IN THE RAT, BINDING IN PLASMA, AND DISAPPEARANCE FROM PLASMA IN THE DOG
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 737
OP 741
VO 1
IS 6
A1 JEROME EDELSON
A1 J. F. DOUGLAS
A1 B. J. LUDWIG
YR 1973
UL http://dmd.aspetjournals.org/content/1/6/737.abstract
AB In the rat, orally administered seclazone, which is stable in the gastrointestinal tract, is rapidly converted to its metabolite, 5-chlorosalicylic acid, by the intestinal wall. The absorption of the drug from the isolated intestine follows first-order kinetics with a half-life of 5 min. Under these conditions, the disappearance of seclazone and of 5-chlorosalicylic acid from the hepatic portal circulation follow apparent first-order kinetics with half-lives of about 5 and 30 min, respectively. No unchanged seclazone could be detected in the systemic circulation after oral administration of drug to either rats or dogs. Both seclazone and 5-chlorosalicylic acid, which was the only compound that could be detected in the blood after oral administration of seclazone, are bound appreciably to plasma proteins. Copyright © 1973 by The American Society for Pharmacology and Experimental Therapeutics