PT  - JOURNAL ARTICLE
AU  - Myers, S R
AU  - Flesher, J W
TI  - Metabolism of the carcinogen 3-methylcholanthrene in human bone marrow preparations.
DP  - 1990 Sep 01
TA  - Drug Metabolism and Disposition
PG  - 664--669
VI  - 18
IP  - 5
4099  - http://dmd.aspetjournals.org/content/18/5/664.short
4100  - http://dmd.aspetjournals.org/content/18/5/664.full
SO  - Drug Metab Dispos1990 Sep 01; 18
AB  - The metabolism of 3-methylcholanthrene was investigated by incubating the hydrocarbon with human bone marrow preparations in air for 60 min at 37 degrees C. The major metabolites were identified by HPLC and GC/MS as 1-hydroxy-3-methylcholanthrene, 1-keto-3-methylcholanthrene, and cholanthrene. The results demonstrate that the potent carcinogen, 3-methylcholanthrene, can undergo biochemical reactions in preparations of human bone marrow, giving rise to the formation of metabolites which are known to be carcinogenic in rats and mice.