PT - JOURNAL ARTICLE AU - Myers, S R AU - Flesher, J W TI - Metabolism of the carcinogen 3-methylcholanthrene in human bone marrow preparations. DP - 1990 Sep 01 TA - Drug Metabolism and Disposition PG - 664--669 VI - 18 IP - 5 4099 - http://dmd.aspetjournals.org/content/18/5/664.short 4100 - http://dmd.aspetjournals.org/content/18/5/664.full SO - Drug Metab Dispos1990 Sep 01; 18 AB - The metabolism of 3-methylcholanthrene was investigated by incubating the hydrocarbon with human bone marrow preparations in air for 60 min at 37 degrees C. The major metabolites were identified by HPLC and GC/MS as 1-hydroxy-3-methylcholanthrene, 1-keto-3-methylcholanthrene, and cholanthrene. The results demonstrate that the potent carcinogen, 3-methylcholanthrene, can undergo biochemical reactions in preparations of human bone marrow, giving rise to the formation of metabolites which are known to be carcinogenic in rats and mice.