TY - JOUR T1 - Metabolism of the carcinogen 3-methylcholanthrene in human bone marrow preparations. JF - Drug Metabolism and Disposition JO - Drug Metab Dispos SP - 664 LP - 669 VL - 18 IS - 5 AU - S R Myers AU - J W Flesher Y1 - 1990/09/01 UR - http://dmd.aspetjournals.org/content/18/5/664.abstract N2 - The metabolism of 3-methylcholanthrene was investigated by incubating the hydrocarbon with human bone marrow preparations in air for 60 min at 37 degrees C. The major metabolites were identified by HPLC and GC/MS as 1-hydroxy-3-methylcholanthrene, 1-keto-3-methylcholanthrene, and cholanthrene. The results demonstrate that the potent carcinogen, 3-methylcholanthrene, can undergo biochemical reactions in preparations of human bone marrow, giving rise to the formation of metabolites which are known to be carcinogenic in rats and mice. ER -