RT Journal Article SR Electronic T1 Metabolism of the carcinogen 3-methylcholanthrene in human bone marrow preparations. JF Drug Metabolism and Disposition JO Drug Metab Dispos FD American Society for Pharmacology and Experimental Therapeutics SP 664 OP 669 VO 18 IS 5 A1 Myers, S R A1 Flesher, J W YR 1990 UL http://dmd.aspetjournals.org/content/18/5/664.abstract AB The metabolism of 3-methylcholanthrene was investigated by incubating the hydrocarbon with human bone marrow preparations in air for 60 min at 37 degrees C. The major metabolites were identified by HPLC and GC/MS as 1-hydroxy-3-methylcholanthrene, 1-keto-3-methylcholanthrene, and cholanthrene. The results demonstrate that the potent carcinogen, 3-methylcholanthrene, can undergo biochemical reactions in preparations of human bone marrow, giving rise to the formation of metabolites which are known to be carcinogenic in rats and mice.