RT Journal Article
SR Electronic
T1 Metabolism of the carcinogen 3-methylcholanthrene in human bone marrow preparations.
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 664
OP 669
VO 18
IS 5
A1 Myers, S R
A1 Flesher, J W
YR 1990
UL http://dmd.aspetjournals.org/content/18/5/664.abstract
AB The metabolism of 3-methylcholanthrene was investigated by incubating the hydrocarbon with human bone marrow preparations in air for 60 min at 37 degrees C. The major metabolites were identified by HPLC and GC/MS as 1-hydroxy-3-methylcholanthrene, 1-keto-3-methylcholanthrene, and cholanthrene. The results demonstrate that the potent carcinogen, 3-methylcholanthrene, can undergo biochemical reactions in preparations of human bone marrow, giving rise to the formation of metabolites which are known to be carcinogenic in rats and mice.