TY - JOUR T1 - Ciprofloxacin does not impair the elimination of diazepam in humans. JF - Drug Metabolism and Disposition JO - Drug Metab Dispos SP - 954 LP - 957 VL - 18 IS - 6 AU - W J Wijnands AU - J F Trooster AU - P C Teunissen AU - H A Cats AU - T B Vree Y1 - 1990/11/01 UR - http://dmd.aspetjournals.org/content/18/6/954.abstract N2 - The pharmacokinetics of a single iv dose of 10 mg diazepam and the renal excretion of its metabolites resulting from N-demethylation and C-3-hydroxylation were investigated in 10 healthy volunteers when diazepam was administered alone and on day 3 of administration of the fluoroquinolone ciprofloxacin (500 mg twice per day). No significant changes in the diazepam half-life, its volume of distribution, the total body clearance, or the renal clearance were observed. In addition, the renal excretion of the metabolites desmethyldiazepam, 3-hydroxydiazepam (temazepam), and 3-hydroxydesmethyldiazepam (oxazepam) were not altered by ciprofloxacin co-medication. These data demonstrate that in a 500 mg twice per day oral dosage, ciprofloxacin does not influence the metabolic clearance of diazepam in young healthy volunteers. ER -