PT  - JOURNAL ARTICLE
AU  - Khor, S P
AU  - Bozigian, H
AU  - Mayersohn, M
TI  - Potential error in the measurement of tissue to blood distribution coefficients in physiological pharmacokinetic modeling. Residual tissue blood. II. Distribution of phencyclidine in the rat.
DP  - 1991 Mar 01
TA  - Drug Metabolism and Disposition
PG  - 486--490
VI  - 19
IP  - 2
4099  - http://dmd.aspetjournals.org/content/19/2/486.short
4100  - http://dmd.aspetjournals.org/content/19/2/486.full
SO  - Drug Metab Dispos1991 Mar 01; 19
AB  - A model for predicting the magnitude of error (% Err) in measuring tissue concentrations of a compound that have not been corrected for residual blood in the tissue was previously developed. The model was tested using data for phencyclidine tissue distribution in the rat. It is shown that % Err may be expressed as a function of volume fraction of blood in tissue (VF)B and tissue-to-blood distribution coefficient. Correction for residual blood is important when the volume fraction of the blood in the tissue is large and when the compound is not taken up substantially by the tissue. On the other hand, a correction may not be necessary when (VF)B is small and uptake of the compound into the tissue is substantial.