TY - JOUR T1 - Isolation and identification of a novel human metabolite of cyclosporin A: dihydro-CsA M17. JF - Drug Metabolism and Disposition JO - Drug Metab Dispos SP - 68 LP - 71 VL - 18 IS - 1 AU - G P Meier AU - S B Park AU - G C Yee AU - D J Gmur Y1 - 1990/01/01 UR - http://dmd.aspetjournals.org/content/18/1/68.abstract N2 - A novel metabolite of cyclosporin A was observed in human blood and urine. An analytical sample of this metabolite was isolated from human urine and the structure was determined to be (8-hydroxy-6,7-dihydro-MeBMT1) cyclosporin based on the 1H-NMR, 13C-NMR, FAB-MS, and HPLC characteristics of the biological sample as well as by comparison with a synthetically derived authentic sample. The significance of this metabolite in terms of the pathway by which cyclosporin A is metabolized is discussed. ER -