RT Journal Article
SR Electronic
T1 ISOLATION OF PENTAERYTHRITOL NITRATES AND THEIR GLUCURONIDES
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 40
OP 45
VO 2
IS 1
A1 FRANZ-JOSEF LEINWEBER
A1 MYRIAM D. MELGAR
A1 MALCOLM C. CREW
A1 FREDERICK J. DI CARLO
YR 1974
UL http://dmd.aspetjournals.org/content/2/1/40.abstract
AB 14C-Labeled pentaerythritol (PE) mononitrate and dinitrate were isolated from 14C-PE trinitrate hydrolysates by adsorption chromatography on Sephadex. Glucuronides of the mono-, di-, and trinitrates of PE were obtained by applying counter-current distribution techniques to the urine and bile of rats treated with 14C-PE trinitrate. PE glucuronide was not detected in this urine or bile, and could not be biosynthesized from PE either by direct glucuronidation with uridine diphosphate glucuronic acid or by transglucuronidation with phenolphthalein glucuronide. Copyright © 1974 by The American Society for Pharmacology and Experimental Therapeutics