PT  - JOURNAL ARTICLE
AU  - MYRIAM D. MELGAR
AU  - FRANZ-JOSEF LEINWEBER
AU  - MALCOLM C. CREW
AU  - FREDERICK J. DI CARLO
TI  - DENITRATION OF UNCONJUGATED AND CONJUGATED PENTAERYTHRITOL NITRATES BY RAT LIVER CYTOSOL
DP  - 1974 Jan 01
TA  - Drug Metabolism and Disposition
PG  - 46--52
VI  - 2
IP  - 1
4099  - http://dmd.aspetjournals.org/content/2/1/46.short
4100  - http://dmd.aspetjournals.org/content/2/1/46.full
SO  - Drug Metab Dispos1974 Jan 01; 2
AB  - Evaluated simultaneously for susceptibility to denitration by the same preparation of rat liver cytosol were pentaerythritol (PE) mononitrate, PE dinitrate, PE trinitrate, and their glucuronides. The only substrates which appeared to resist enzymatic denitration totally were PE mononitrate and PE mononitrate glucuronide. The susceptibility of the other substrates decreased in the sequence: PE trinitrate > PE dinitrate, PE trinitrate glucuronide > PE dinitrate glucuronide. PE and its mono-, di-, and trinitrates were tested for ability to undergo glucuronidation by rat liver microsomes and uridine diphosphate glucuronic acid. The three PE nitrates were comparably amenable to glucuronidation, but PE did not undergo this conjugation. Copyright © 1974 by The American Society for Pharmacology and Experimental Therapeutics