TY - JOUR T1 - Isolation and identification of a novel isomerized epoxide metabolite of FK-506 from erythromycin-induced rabbit liver microsomes. JF - Drug Metabolism and Disposition JO - Drug Metab Dispos SP - 850 LP - 854 VL - 21 IS - 5 AU - G Lhoƫst AU - N Maton AU - R K Verbeeck Y1 - 1993/09/01 UR - http://dmd.aspetjournals.org/content/21/5/850.abstract N2 - A novel metabolite of FK-506-a C13, C15, C31 O-demethyl C19 hydroxymethyl C36 isomerized epoxide of FK-506 obtained from erythromycin-induced rabbit liver microsomes--was isolated by HPLC and identified by FAB/MS and NMR. The existence of ring-chain tautomers for this metabolite is demonstrated by NMR spectroscopy. FAB/MS, and HPLC. ER -