PT  - JOURNAL ARTICLE
AU  - RAJENDRA S. CHHABRA
AU  - JAMES R. FOUTS
TI  - SEX DIFFERENCES IN THE METABOLISM OF XENOBIOTICS BY EXTRAHEPATIC TISSUE IN RATS
DP  - 1974 Jul 01
TA  - Drug Metabolism and Disposition
PG  - 375--379
VI  - 2
IP  - 4
4099  - http://dmd.aspetjournals.org/content/2/4/375.short
4100  - http://dmd.aspetjournals.org/content/2/4/375.full
SO  - Drug Metab Dispos1974 Jul 01; 2
AB  - Liver microsomes from male rats metabolize xenobiotics faster than liver microsomes from female rats. The present study revealed that sex differences in the metabolism of xenobiotics may be specific to only some organs or tissues since enzyme preparations from rat lung and gut did not show sex differences in metabolism of several drug substrates. Rat kidney microsomes exhibited sex differences in rates of hydroxylation of benzpyrene and glucuronidation of p-nitrophenol, although in contrast to liver, the rates of metabolism were higher in kidneys from female than from male rats. The sex differences in both liver and kidney microsomal UDP-glucuronyltransferase activity existed even after maximal activation of the enzyme by Triton x-100. Copyright © 1974 by The American Society for Pharmacology and Experimental Therapeutics