TY - JOUR T1 - Microbial Models of Mammalian Metabolism JF - Drug Metabolism and Disposition JO - Drug Metab Dispos SP - 311 LP - 316 VL - 25 IS - 3 AU - Cecile Moussa AU - Patrick Houziaux AU - Bernard Danree AU - Robert Azerad Y1 - 1997/03/01 UR - http://dmd.aspetjournals.org/content/25/3/311.abstract N2 - A cymene-derived drug, 3-[4′-(o-ethoxyphenyl)piperazin-1′-yl]ethyloxy-p-cymene (B1178), is not significantly metabolized by fungal microorganisms. On the contrary, one of its metabolites in rat, 3-(piperazin-1′-yl)ethoxy-p-cymene (B1071), is quantitatively converted by Cunninghamella echinulata NRRL 3655 into two hydroxylated products: the corresponding phenol derivative and a benzylic alcohol derivative. Other strains, such asBeauveria bassiana ATCC 7159 and Mortierella isabellina MMP 108, produce exclusively an N-acetyl derivative in high yield. Results obtained are discussed on the grounds of relative hydrophobicity of substrates vs. fungi metabolism and detoxification capabilities. The American Society for Pharmacology and Experimental Therapeutics ER -