%0 Journal Article %A BITTEN STRIPP %A I. GLENN SIPES %A HARRIET M. MALING %A JAMES R. GILLETTE %T DIBENAMINE IMPAIRMENT OF RAT HEPATIC MICROSOMAL ENZYMES AND ITS RELATION TO HEPATOTOXICITY INDUCED BY CCl4 AND DIMETHYLNITROSAMINE %D 1974 %J Drug Metabolism and Disposition %P 464-468 %V 2 %N 5 %X Pretreatment of rats with dibenamine ·HCl (25 mg/kg sc 48 and 24 hr before death) decreased the activity of cytochrome P-450-dependent enzymes in hepatic microsomes as judged by the in vitro N-demethylation of ethylmorphine and dimethylnitrosamine and covalent binding of 14CCI4 and 14C-dimethylnitrosamine. The decrease in enzymatic activity is probably not due solely to a decrease in the amount of cytochrome P-450. Dibenamine pretreatment may protect rats from the hepatotoxicity of CCl4 or dimethylnitrosamine by reducing the formation of active metabolites by microsomal enzymes. Copyright © 1974 by The American Society for Pharmacology and Experimental Therapeutics %U https://dmd.aspetjournals.org/content/dmd/2/5/464.full.pdf