RT Journal Article
SR Electronic
T1 Physiological and Pathophysiological Regulation of Cytochrome P450
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 1232
OP 1240
VO 26
IS 12
A1 Edward T. Morgan
A1 Marion B. Sewer
A1 Heinrich Iber
A1 Frank J. Gonzalez
A1 Ying-Hue Lee
A1 Robert H. Tukey
A1 Steve Okino
A1 Tien Vu
A1 Yue-Hwa Chen
A1 Jaspreet S. Sidhu
A1 Curtis J. Omiecinski
YR 1998
UL http://dmd.aspetjournals.org/content/26/12/1232.abstract
AB This article is a report on a symposium sponsored by the American Society for Pharmacology and Experimental Therapeutics and held at the April 1998 Experimental Biology ’98 meeting in San Francisco. The presentations focused on the mechanisms of regulation of cytochrome P450 gene expression by developmental factors and by hormones and cytokines, as well as on the interplay between physiological and chemical regulation. Approaches and systems used to address these questions included conditional gene knockouts in mice, primary hepatocyte cultures, immunofluorescence imaging of cells, and cell lines stably expressing reporter gene constructs. The American Society for Pharmacology and Experimental Therapeutics