PT  - JOURNAL ARTICLE
AU  - Sandra K. Kirkman
AU  - Mei-Yi Zhang
AU  - Peter M. Horwatt
AU  - JoAnn Scatina
TI  - Isolation and Identification of Bromfenac Glucoside From Rat Bile
DP  - 1998 Jul 01
TA  - Drug Metabolism and Disposition
PG  - 720--723
VI  - 26
IP  - 7
4099  - http://dmd.aspetjournals.org/content/26/7/720.short
4100  - http://dmd.aspetjournals.org/content/26/7/720.full
SO  - Drug Metab Dispos1998 Jul 01; 26
AB  - Bromfenac (Duract®), a drug approved for pain, was expected to be metabolized by the rat to an acyl glucuronide, a metabolite formed with most compounds of similar structure. During the investigation of metabolite profiles in rat bile following administration of 1 mg/kg iv doses of14C-bromfenac, an acid-labile metabolite was found that degraded to form 14C-bromfenac. Isolation and characterization of this metabolite indicated that it is an unusual conjugate, bromfenac N-glucoside. The American Society for Pharmacology and Experimental Therapeutics