RT Journal Article
SR Electronic
T1 Deposition of [<sup>3</sup>H]Cocaine, [<sup>3</sup>H]Nicotine, and [<sup>3</sup>H]Flunitrazepam in Mouse Hair Melanosomes after Systemic Administration
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 731
OP 735
VO 27
IS 6
A1 Stout, Peter R.
A1 Ruth, James A.
YR 1999
UL http://dmd.aspetjournals.org/content/27/6/731.abstract
AB Microautoradiography was employed to show that association of drugs from the serum directly with forming hair pigment is a primary pathway of deposition into the hair. After systemic administration of [3H]flunitrazepam, [3H]nicotine, and [3H]cocaine, association of all three drugs with melanin in the forming hair was observed within minutes of dosage. Sebum was determined to be an insignificant deposition route for all three drugs. Pigmented mice had significantly higher concentrations of all three drugs than did nonpigmented mice. The results provide a better basis for ultimately using hair for reliable analysis of drug and environmental toxin exposure. The American Society for Pharmacology and Experimental Therapeutics