PT  - JOURNAL ARTICLE
AU  - Edward T. Morgan
AU  - Volker Ullrich
AU  - Andreas Daiber
AU  - Patrick Schmidt
AU  - Naoki Takaya
AU  - Hirofumi Shoun
AU  - John C. McGiff
AU  - Adebayo Oyekan
AU  - Craig J. Hanke
AU  - William B. Campbell
AU  - Chang-Shin Park
AU  - Ju-Seop Kang
AU  - Hyeon-Gyu Yi
AU  - Young-Nam Cha
AU  - Daniel Mansuy
AU  - Jean-Luc Boucher
TI  - Cytochromes P450 and Flavin Monooxygenases—Targets and Sources of Nitric Oxide
DP  - 2001 Nov 01
TA  - Drug Metabolism and Disposition
PG  - 1366--1376
VI  - 29
IP  - 11
4099  - http://dmd.aspetjournals.org/content/29/11/1366.short
4100  - http://dmd.aspetjournals.org/content/29/11/1366.full
SO  - Drug Metab Dispos2001 Nov 01; 29
AB  - This article is a report on a symposium sponsored by the American Society for Pharmacology and Experimental Therapeutics and held at the Experimental Biology 01 meeting in Orlando, FL. The presentations addressed the mechanisms of inhibition and regulation of cytochrome P450 and flavin monooxygenase enzymes by nitric oxide. They also highlighted the consequences of these effects on metabolism of drugs and volatile amines as well as on important physiological parameters, such as control of blood pressure, renal ion transport, and steroidogenesis. This is achieved via regulation of P450-dependent prostacyclin, hydroxyeicosatetraenoic acid, and epoxyeicosatrienoic acid formation. Conversely, the mechanisms and relative importance of nitric oxide synthases and P450 enzymes in NO production from endogenous and synthetic substrates were also addressed. The American Society for Pharmacology and Experimental Therapeutics