RT Journal Article
SR Electronic
T1 Cytochromes P450 and Flavin Monooxygenases—Targets and Sources of Nitric Oxide
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 1366
OP 1376
VO 29
IS 11
A1 Edward T. Morgan
A1 Volker Ullrich
A1 Andreas Daiber
A1 Patrick Schmidt
A1 Naoki Takaya
A1 Hirofumi Shoun
A1 John C. McGiff
A1 Adebayo Oyekan
A1 Craig J. Hanke
A1 William B. Campbell
A1 Chang-Shin Park
A1 Ju-Seop Kang
A1 Hyeon-Gyu Yi
A1 Young-Nam Cha
A1 Daniel Mansuy
A1 Jean-Luc Boucher
YR 2001
UL http://dmd.aspetjournals.org/content/29/11/1366.abstract
AB This article is a report on a symposium sponsored by the American Society for Pharmacology and Experimental Therapeutics and held at the Experimental Biology 01 meeting in Orlando, FL. The presentations addressed the mechanisms of inhibition and regulation of cytochrome P450 and flavin monooxygenase enzymes by nitric oxide. They also highlighted the consequences of these effects on metabolism of drugs and volatile amines as well as on important physiological parameters, such as control of blood pressure, renal ion transport, and steroidogenesis. This is achieved via regulation of P450-dependent prostacyclin, hydroxyeicosatetraenoic acid, and epoxyeicosatrienoic acid formation. Conversely, the mechanisms and relative importance of nitric oxide synthases and P450 enzymes in NO production from endogenous and synthetic substrates were also addressed. The American Society for Pharmacology and Experimental Therapeutics