RT Journal Article
SR Electronic
T1 Cytochromes P450 and Flavin Monooxygenases—Targets and Sources of Nitric Oxide
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 1366
OP 1376
VO 29
IS 11
A1 Morgan, Edward T.
A1 Ullrich, Volker
A1 Daiber, Andreas
A1 Schmidt, Patrick
A1 Takaya, Naoki
A1 Shoun, Hirofumi
A1 McGiff, John C.
A1 Oyekan, Adebayo
A1 Hanke, Craig J.
A1 Campbell, William B.
A1 Park, Chang-Shin
A1 Kang, Ju-Seop
A1 Yi, Hyeon-Gyu
A1 Cha, Young-Nam
A1 Mansuy, Daniel
A1 Boucher, Jean-Luc
YR 2001
UL http://dmd.aspetjournals.org/content/29/11/1366.abstract
AB This article is a report on a symposium sponsored by the American Society for Pharmacology and Experimental Therapeutics and held at the Experimental Biology 01 meeting in Orlando, FL. The presentations addressed the mechanisms of inhibition and regulation of cytochrome P450 and flavin monooxygenase enzymes by nitric oxide. They also highlighted the consequences of these effects on metabolism of drugs and volatile amines as well as on important physiological parameters, such as control of blood pressure, renal ion transport, and steroidogenesis. This is achieved via regulation of P450-dependent prostacyclin, hydroxyeicosatetraenoic acid, and epoxyeicosatrienoic acid formation. Conversely, the mechanisms and relative importance of nitric oxide synthases and P450 enzymes in NO production from endogenous and synthetic substrates were also addressed. The American Society for Pharmacology and Experimental Therapeutics