RT Journal Article
SR Electronic
T1 Regulation of Cytochrome P450 by Inflammatory Mediators: Why and How?
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 207
OP 212
VO 29
IS 3
A1 Edward T. Morgan
YR 2001
UL http://dmd.aspetjournals.org/content/29/3/207.abstract
AB Expression and activities of cytochrome P450 enzymes are down-regulated in the liver during the host response to inflammation or infection, leading to alterations in drug clearance and toxin activation. This review focuses on recent studies on the mechanisms of this down-regulation, as well as the cytokines and cell types involved. Possible reasons for cytochrome P450 down-regulation are discussed. The American Society for Pharmacology and Experimental Therapeutics