RT Journal Article SR Electronic T1 Genotype and Severity of Long QT Syndrome JF Drug Metabolism and Disposition JO Drug Metab Dispos FD American Society for Pharmacology and Experimental Therapeutics SP 574 OP 579 VO 29 IS 4 A1 Jeffrey A. Towbin A1 Zhiqing Wang A1 Hua Li YR 2001 UL http://dmd.aspetjournals.org/content/29/4/574.abstract AB Sudden cardiac death occurs in the United States with an incidence greater than 300,000 persons per year. The underlying cause of death is commonly considered to be due to primary or secondary arrhythmias. In cases in which no structural heart disease can be identified, the long QT syndromes (LQTS) are now commonly considered as likely causes. Multiple genes causing LQTS have been identified thus far, all encoding cardiac ion channels. These include two potassium channel α-subunits (KVLQT1, HERG), two potassium channel β-subunits (minK, MiRP1), and one sodium channel gene (SCN5A). The purpose of this review is to describe the current understanding of the molecular genetics of LQTS and the resultant phenotypes. The American Society for Pharmacology and Experimental Therapeutics