RT Journal Article
SR Electronic
T1 Diversity of Mechanism-Based Pharmacodynamic Models
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 510
OP 518
DO 10.1124/dmd.31.5.510
VO 31
IS 5
A1 Donald E. Mager
A1 Elzbieta Wyska
A1 William J. Jusko
YR 2003
UL http://dmd.aspetjournals.org/content/31/5/510.abstract
AB Pharmacodynamics is the study of the time course of pharmacological effects of drugs. The field of pharmacodynamic modeling has made many advances, due in part to the relatively recent development of basic and extended mechanism-based models. The purpose of this article is to describe the classic as well as contemporary approaches, with an emphasis on pertinent equations and salient model features. In addition, current methods of integrating various system complexities into these models are discussed. Future pharmacodynamic models will most likely reflect an assembly of the basic components outlined in this review. The American Society for Pharmacology and Experimental Therapeutics