TY - JOUR T1 - GLUCURONIDATION AND THE UDP-GLUCURONOSYLTRANSFERASES IN HEALTH AND DISEASE JF - Drug Metabolism and Disposition JO - Drug Metab Dispos SP - 281 LP - 290 DO - 10.1124/dmd.32.3.281 VL - 32 IS - 3 AU - Peter G. Wells AU - Peter I. Mackenzie AU - Jayanta Roy Chowdhury AU - Chantal Guillemette AU - Philip A. Gregory AU - Yuji Ishii AU - Antony J. Hansen AU - Fay K. Kessler AU - Perry M. Kim AU - Namita Roy Chowdhury AU - Joseph K. Ritter Y1 - 2004/03/01 UR - http://dmd.aspetjournals.org/content/32/3/281.abstract N2 - This article is an updated report of a symposium held at the June 2000 annual meeting of the American Society for Pharmacology and Experimental Therapeutics in Boston. The symposium was sponsored by the ASPET Divisions for Drug Metabolism and Molecular Pharmacology. The report covers research from the authors' laboratories on the structure and regulation of UDP-glucuronosyltransferase (UGT) genes, glucuronidation of xenobiotics and endobiotics, the toxicological relevance of UGTs, the role of UGT polymorphisms in cancer susceptibility, and gene therapy for UGT deficiencies. The American Society for Pharmacology and Experimental Therapeutics ER -