RT Journal Article
SR Electronic
T1 GLUCURONIDATION AND THE UDP-GLUCURONOSYLTRANSFERASES IN HEALTH AND DISEASE
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 281
OP 290
DO 10.1124/dmd.32.3.281
VO 32
IS 3
A1 Wells, Peter G.
A1 Mackenzie, Peter I.
A1 Roy Chowdhury, Jayanta
A1 Guillemette, Chantal
A1 Gregory, Philip A.
A1 Ishii, Yuji
A1 Hansen, Antony J.
A1 Kessler, Fay K.
A1 Kim, Perry M.
A1 Roy Chowdhury, Namita
A1 Ritter, Joseph K.
YR 2004
UL http://dmd.aspetjournals.org/content/32/3/281.abstract
AB This article is an updated report of a symposium held at the June 2000 annual meeting of the American Society for Pharmacology and Experimental Therapeutics in Boston. The symposium was sponsored by the ASPET Divisions for Drug Metabolism and Molecular Pharmacology. The report covers research from the authors' laboratories on the structure and regulation of UDP-glucuronosyltransferase (UGT) genes, glucuronidation of xenobiotics and endobiotics, the toxicological relevance of UGTs, the role of UGT polymorphisms in cancer susceptibility, and gene therapy for UGT deficiencies. The American Society for Pharmacology and Experimental Therapeutics