RT Journal Article
SR Electronic
T1 THE DECREASE IN LEVEL OF SERUM THYROXINE BY 2,2′,4,5,5′-PENTACHLOROBIPHENYL IN RATS AND MICE: NO CORRELATION WITH FORMATION OF METHYLSULFONYL METABOLITES
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 1661
OP 1665
DO 10.1124/dmd.105.006189
VO 33
IS 11
A1 Kato, Yoshihisa
A1 Haraguchi, Koichi
A1 Yamazaki, Tomoaki
A1 Kimura, Ryohei
A1 Koga, Nobuyuki
A1 Yamada, Shizuo
A1 Degawa, Masakuni
YR 2005
UL http://dmd.aspetjournals.org/content/33/11/1661.abstract
AB A relationship between formation of methylsulfonyl (MeSO2) metabolites of 2,2′,4,5,5′-pentachlorobiphenyl (PentaCB) and decrease in serum thyroxine (T4) level was examined in the rats and mice after a single i.p. injection of PentaCB (342 μmol/kg body weight). In either rats or mice, levels of the 3- and 4-MeSO2 metabolites of PentaCB in the liver and feces increased in a time-dependent fashion up to 8 days after PentaCB-treatment. However, there was a marked difference between rats and mice in the amount of the metabolites formed, and the cumulative amount of the either MeSO2 metabolite for 8 days after PentaCB treatment in the liver was 4 to 15 times higher in mice than in rats. On the other hand, a 40 to 60% decrease in level of serum total T4 occurred in both rats and mice at 1 day after PentaCB treatment, and the decrease was retained up to 8 days after PentaCB treatment. Thus, there was a marked difference between rats and mice in the formation of MeSO2 metabolites from PentaCB but not a significant difference between rats and mice in PentaCB-induced decrease in the level of serum total T4, indicating that PentaCB-induced decrease in the level of serum total T4 is not necessarily dependent on the MeSO2 metabolites formed. The American Society for Pharmacology and Experimental Therapeutics