RT Journal Article
SR Electronic
T1 METABOLISM OF PROPIONYL ERYTHROMYCIN LAURYL SU LFATE
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 164
OP 170
VO 3
IS 3
A1 PATRICK J. MURPHY
A1 TERRY L. WILLIAMS
A1 ROBERT E. McMAHON
A1 ROSS E. CRABTREE
A1 ANTHONY S. RIDOLFO
YR 1975
UL http://dmd.aspetjournals.org/content/3/3/164.abstract
AB The absorption. excretion. and metabolism of [1-14]lauryl sulfate as either the sodium or propionyl erythromycin salt has been studied in the rat and man. In the rat 88% of the radiolabel from propionyl erythromycin [1-14]lauryl sulfate was excreted in the urine in the 24-hr period following a single oral dose. More than 95% of the radiolabel was excreted as the metabolite butyric acid 4-sulfate. This metabolite was shown to be derived from carbons 1 -4 of the lauryl sulfate moiety. There was no evidence of sulfate cleavage in the rat. In man 5 1 -59% of the administered radioactivity was recovered in the urine. The major excretion product was butyric acid 4-sulfate accounting for approximately 95% of urinary radioactivity. The remainder was unchanged lauryl sulfate. A significant portion of the radiolabeled propionyl erythromycin lauryl sulfate was converted to 14C02 indicating that the sulfate linkage was cleaved. A minimum value of 9-16% of the dose was metabolized in this manner. Copyright © 1975 by The American Society for Pharmacology and Experimental Therapeutics