TY - JOUR T1 - Differential Allelic Expression in Leukoblast from Patients with Acute Myeloid Leukemia Suggests Genetic Regulation of <em>CDA</em>, <em>DCK</em>, <em>NT5C2</em>, <em>NT5C3</em>, and <em>TP53</em> JF - Drug Metabolism and Disposition JO - Drug Metab Dispos SP - 2419 LP - 2423 DO - 10.1124/dmd.108.023184 VL - 36 IS - 12 AU - L. P. Jordheim AU - T. Nguyen-Dumont AU - X. Thomas AU - C. Dumontet AU - S. V. Tavtigian Y1 - 2008/12/01 UR - http://dmd.aspetjournals.org/content/36/12/2419.abstract N2 - mRNA expression levels of certain genes have shown predictive value for the outcome of cytarabine-treated AML-patients. We hypothesized that genetic variants play a role in the regulation of the transcription of these genes. We studied leukoblasts from 82 patients with acute myeloid leukemia and observed various extent and frequency of differential allelic expression in the CDA, DCK, NT5C2, NT5C3, and TP53 genes. Our attempts to identify the causative regulatory single nucleotide polymorphisms by a bioinformatics approach did not succeed. However, our results indicate that genetic variations are at least in part responsible for the differences in overall expression levels of these genes. The American Society for Pharmacology and Experimental Therapeutics ER -