%0 Journal Article %A R. M. DE SAGHER %A A. P. DE LEENHEER %A A. A. CRUYL %A A. E. CLAEYS %T IDENTIFICATION AND URINARY EXCRETION OF p-CHLOROPHENOXYACETAMIDE, A METABOLITE OF IPROCLOZIDE, IN HUMANS %D 1975 %J Drug Metabolism and Disposition %P 423-429 %V 3 %N 6 %X The presence of p-chlorophenoxyacetamide was detected in the urine of man receiving iproclozide [1-(p-chlorophenoxyacetyl)-2-isopropylhydrazine]. This new metabolite was identified by combined gas-liquid chromatography-mass spectrometry and by comparison with the synthetic compound. An appropriate procedure for the extraction and quantitation of p-chlorophenoxyacetamide by gas-liquid chromatography on a 5% OV-225-packed column with the 2-butyl analog of iproclozide as an internal standard, has been developed. After 20- and 50-mg single dose oral administrations of iproclozide, 5.2 and 8.3% were slowly excreted in urine as p-chlorophenoxyacetamide within 30.5 and 36 hr, respectively. After 20-mg oral intakes by psychiatric patients, the 24-hr urinary excretion of p-chlorophenoxyacetamide amounted to about 2-4% of the iproclozide dose administered. Copyright © 1975 by The American Society for Pharmacology and Experimental Therapeutics %U https://dmd.aspetjournals.org/content/dmd/3/6/423.full.pdf