RT Journal Article
SR Electronic
T1 N-HYDROXYAMOBARBITAL: THE SECOND MAJOR METABOLITE OF AMOBARBITAL IN MAN
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 479
OP 486
VO 3
IS 6
A1 B. K. TANG
A1 T. INABA
A1 W. KALOW
YR 1975
UL http://dmd.aspetjournals.org/content/3/6/479.abstract
AB After oral administration of 14C-labeled amobarbital to healthy subjects, most of the radioactivity was recovered in urine and only 4-5% in feces over a period of 6 days. No unchanged amobarbital was excreted. Two major metabolites were found and isolated. One was 3'-hydroxyamobarbital, which has been previously identified by Maynert. The second could be identified as N-hydroxyamobarbital on the basis of its spectral and chemical properties. Copyright © 1975 by The American Society for Pharmacology and Experimental Therapeutics