PT  - JOURNAL ARTICLE
AU  - P. J. POPPERS
AU  - W. LEVIN
AU  - A. H. CONNEY
TI  - EFFECT OF 3-METHYLCHOLANTHRENE TREATMENT ON PHENACETIN O-DEALKYLATION IN SEVERAL INBRED MOUSE STRAINS
DP  - 1975 Nov 01
TA  - Drug Metabolism and Disposition
PG  - 502--506
VI  - 3
IP  - 6
4099  - http://dmd.aspetjournals.org/content/3/6/502.short
4100  - http://dmd.aspetjournals.org/content/3/6/502.full
SO  - Drug Metab Dispos1975 Nov 01; 3
AB  - An increase in the metabolism of phenacetin to N-acetyl-p-aminophenol is correlated with benzo[a]pyrene hydroxylase induction by 3-methylcholanthrene among several inbred mouse strains. While the magnitude of induction of phenacetin O-dealkylation is considerably less than that of benzo[a]pyrene hydroxylation, the data indicate that in mice, the metabolism of these two substrates is under similar regulatory control. Copyright © 1975 by The American Society for Pharmacology and Experimental Therapeutics