TY - JOUR T1 - In Vitro Inhibition of Multiple Cytochrome P450 Isoforms by Xanthone Derivatives from Mangosteen Extract JF - Drug Metabolism and Disposition JO - Drug Metab Dispos SP - 1848 LP - 1855 DO - 10.1124/dmd.109.028043 VL - 37 IS - 9 AU - Robert S. Foti AU - Josh T. Pearson AU - Dan A. Rock AU - Jan L. Wahlstrom AU - Larry C. Wienkers Y1 - 2009/09/01 UR - http://dmd.aspetjournals.org/content/37/9/1848.abstract N2 - Mangosteen is a xanthone-containing fruit found in Southeast Asia for which health claims include maintaining healthy immune and gastrointestinal systems to slowing the progression of tumor growth and neurodegenerative diseases. Previous studies have identified multiple xanthones in the pericarp of the mangosteen fruit. The aim of the current study was to assess the drug inhibition potential of mangosteen in vitro as well as the cytochrome P450 (P450) enzymes responsible for the metabolism of its individual components. The various xanthone derivatives were found to be both substrates and inhibitors for multiple P450 isoforms. Aqueous extracts of the mangosteen pericarp were analyzed for xanthone content as well as inhibition potency. Finally, in vivo plasma concentrations of α-mangostin, the most abundant xanthone derivative found in mangosteen, were predicted using Simcyp and found to be well above their respective in vitro Ki values for CYP2C8 and CYP2C9. ER -