TY - JOUR T1 - Impact of the <em>CYP2C19</em>*<em>17</em> Allele on the Pharmacokinetics of Omeprazole and Pantoprazole in Children: Evidence for a Differential Effect JF - Drug Metabolism and Disposition JO - Drug Metab Dispos SP - 894 LP - 897 DO - 10.1124/dmd.109.030601 VL - 38 IS - 6 AU - Gregory L. Kearns AU - J. Steven Leeder AU - Andrea Gaedigk Y1 - 2010/06/01 UR - http://dmd.aspetjournals.org/content/38/6/894.abstract N2 - The impact of the CYP2C19*17 allele on the pharmacokinetics of pantoprazole and omeprazole in previously studied children (n = 40) was explored. When pantoprazole area under the plasma concentration versus time curve (AUC) was examined as a function of CYP2C19 genotype, a significantly lower AUC was observed for subjects identified as CYP2C19*1/*1 and *1/*17. For pantoprazole, a statistically significant relationship was observed between CYP2C19 genotype and both dose-corrected AUC (p &lt; 0.0001) and the apparent elimination rate constant (Kel; p = 0.0012); no significant genotype-phenotype relationships were observed for omeprazole. Copyright © 2010 by The American Society for Pharmacology and Experimental Therapeutics ER -