RT Journal Article
SR Electronic
T1 Microsomal glucuronidation of a quaternary ammonium compound, 3-hydroxyphenyltrimethylammonium.
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 15
OP 18
VO 5
IS 1
A1 Somani, S M
A1 Anderson, J H
YR 1977
UL http://dmd.aspetjournals.org/content/5/1/15.abstract
AB 3-Hydroxyphenyltrimethylammonium (HPTMA) is glucuronidated in vitro by rat liver microsomes supplemented with UDP-glucuronic acid. Little reaction occurred in the postmicrosomal supernatant fraction. Triton X-100 doubled the maximal velocity for the microsomecatalyzed reaction without altering the apparent KM value for HPTMA. This is the first report of glucuronidation of a quaternary ammonium compound in vitro.