RT Journal Article
SR Electronic
T1 Plasma levels of real and "apparent" hydralazine in man and rat.
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 116
OP 121
VO 5
IS 2
A1 S B Zak
A1 G Lukas
A1 T G Gilleran
YR 1977
UL http://dmd.aspetjournals.org/content/5/2/116.abstract
AB Derivatization of hydralazine in plasma under acidic conditions yields values for the concentrations of "apparent" hydralazine that are dependent on the pH in the derivatization step. The results have been explained by postulating the existence of acid-hydrolyzable conjugates of unknown structure. These metabolites appear to be present in rat and human plasma after oral dosing. Procedures have been developed for the selective analysis of hydralazine or its acid-labile conjugates, and applied to measurements of plasma concentrations in rat and man.